My Secret Mitochondrial Sauce… Finally Revealed!

Living a long, active life largely depends on the health and well-being of your mitochondria and cellular genetic material. Researchers are confirming the ability of certain plant substances to profoundly affect mitochondrial health, much like or even surpassing the effects seen with calorie restriction.


I’m often asked what really matters when it comes to living a long, healthy life. If you asked me that question 10 years ago, you would have received a much different answer than the one I’d give today.

What we’ve learned about longevity and health in the last decade is nothing short of astonishing.

I am confident that you likely want to live as many productive, enjoyable and comfortable years as possible. So do I.

That’s why I’m going to pull back the curtains and share with you some of the most exciting research I’ve seen to date on this topic.

senior active life
Most people want to enjoy a healthy, active life well into their senior years

I believe these discoveries hold much potential, especially since today we’re surrounded by health-wrecking forces like EMFs, pollution, herbicides and pesticides in our food and water, declining nutrients in our soils, and countless untested chemicals in the items we use every day.

The ability to live a long, active life boils down to the health of your mitochondria and the integrity of the genetic material housed within your cells. All of the factors I just named ultimately impact both.

You must have an effective way of protecting your cells from these assaults or your health will pay the price. And some researchers now believe you may only have a 10-year window before free radical and oxidative damage becomes irreversible.

When that window started for you is anyone’s guess…

I’m convinced there’s not much time to spare. That’s why I’ve come up with what I’m calling my “mitochondrial sauce” – a blend of four plant substances that offer tremendous hope for cellular and mitochondrial health, based on the most cutting edge longevity research.

We Know We Can Extend an Animal’s Life… What About Yours?

calorie restriction
Calorie restriction allows your mitochondria to regenerate themselves

In animal studies, calorie restriction appears to slow down the aging process.

When rhesus monkeys were fed about a third less calories, their healthy lifespan and survival rates increased significantly compared to the study control group.

When you restrict your calories or fast, many beneficial changes take place, including these three keys things:

  • Your body shifts into a protective and regenerative mode
  • Your cells and tissues double down to fight damaging free radicals and repair its genetic materials
  • Your mitochondria undergo mitochondrial biogenesis, the process of replacing old, malfunctioning mitochondria with new ones

Fasting and the restriction of calories and non-fiber carbohydrates help activate your mitochondria. When there’s no or limited glucose available for energy, your body must rely on lipids and stored fats. This forces your cells to use their mitochondria, as they are their only means of producing energy from fat.

Shifting over to using fat for fuel instead of glucose is a profoundly effective way to help optimize your mitochondrial health. Targeted nutritional ketosis and intermittent fasting are two tools I personally use and teach to others. You can find out more about both of these in my bestselling book Fat for Fuel.

Beyond Calorie Restriction: This Natural Substance Tricks Your Body Into Regeneration Mode

What if there were other ways to get the same longevity effects as fasting – without actually restricting your calories?

This brings me to what I’ve learned from the latest research...

hallmarks of aging
A hallmark of aging is decreased numbers of healthy mitochondria

Researchers have isolated plant substances that mimic the effects of calorie restriction to help protect your mitochondria and genetic material, and to help slow premature aging.

One of the most significant hallmarks of aging is decreased numbers of healthy mitochondria.

The more undamaged, fully functioning mitochondria you have in your cells, the greater your odds are of living a long healthy life.

As you age, your mitochondria become progressively more damaged through oxidative stresses. Communication breaks down in large part to the age-related decline of a coenzyme found in all living cells: Nicotinamide adenine dinucleotide, or NAD+.

NAD+, sometimes called the “Molecule of Youth”, is essential for fueling the activity of sirtuins, including SIRT1 and SIRT3, two master regulators of aging.

SIRT1 and SIRT3 are proteins that require NAD+ to function. All are needed to effectively trigger the formation and optimal functioning of new mitochondria.

Your levels of NAD+ drop as you age, so your sirtuin activity declines as well. That impacts cellular signaling, which leads to mitochondrial dysfunction.

Transformed: The Equivalent of a 60-Year-Old to a 20-Year-Old Human in Just ONE Week

Effects of NAD + in mice
A stunning 2013 study demonstrates the effects of NAD+ on the signs of aging in mice

The remarkable effects of NAD+ on aging have been shown in mice studies.

In one recent study, researchers artificially boosted a group of elderly mice’s NAD+ levels with an injected pharmaceutical compound known to increase cellular levels of NAD+.

Within only one week of treatment, mitochondrial homeostasis was restored and the key biochemical markers of muscle health in a 22-month-old “old” mouse were restored to levels similar to a youthful 6-month-old mouse.

To appreciate that in human years, that’s like transforming the biochemical markers of a 60-year-old body to those of a 20-year-old!

How did this compound create such astounding changes?

It restored a high ratio of NAD+ to NADH, a cofactor that plays a key role in the production of energy. High levels of NAD+ (relative to NAHD) are needed for DNA repair and the activation of SIRT1.

This study impressed me, but I typically avoid the use of pharmaceuticals to increase my levels of NAD+. That’s what led me to look closer at one of my favorite teas…

Mice Fed This Plant-Sourced NAD Precursor Lived Even LONGER Than the Calorie-Restricted Group

I’ve been intrigued with Pau d'Arco’s potential benefits for health and longevity for a while now. This South American tree, also known as Lapacho, has been used as a tea for a number of health issues since at least 1873.

The most valuable part of the tree is the inner lining of the bark. It contains a substance called beta-lapachone, which powerfully increases, or up-regulates NAD+ inside your cells. 

In a study with aged mice, researchers added beta-lapachone from Pau d’Arco bark into one group’s diet. With no other change in activity level or total calories, the following effects were noted, compared to the control group:

Pau d'Arco mimics
Pau d'Arco mimics and even surpasses the effects of calorie restriction without limiting calories
  • Increased ratio of NAD+ to NADH in the muscle
  • Higher number of intact mitochondria with normal structure, suggesting resistance to mitochondrial breakdown
  • Less damage to mitochondrial proteins that reduce the production of damaging reactive oxygen species (ROS) inside the cell
  • A decrease in body weight and body mass, compared to the level found in young adult mice
  • Lower age-related markers in blood, such as increased glucose, lipids, and leptin
  • Increased body temperature, suggesting a higher energy expenditure and body metabolism
  • Higher capacity of associative memory
  • Greater motor performance and muscular strength, as seen by up-regulated genes associated with muscle development

Surprisingly, beta-lapachone benefited the health of the mice even more than calorie restriction. The beta-lapachone group lived significantly longer than the calorie-restricted group, which lived significantly longer than the control group!

In addition, the researchers noted that beta-lapachone protected the mitochondrial structure better than calorie restriction.

Beta-Lapachone and Brown Fat: Another Key to Youthful Aging?

baby fat
Baby fat contains high levels of brown fat rich with mitochondria

For years, researchers believed that brown adipose tissue, or brown fat, existed mostly in two groups: newborn infants and hibernating mammals.

Serving an important role for these two groups, brown fat is crucial for thermoregulation and stimulating energy expenditure by producing heat. Brown fat is especially rich in mitochondria.

As an adult, you have both white and brown adipose tissue, but your brown fat deposits have drastically declined with age. What you have left is around your spinal cord, kidneys, neck, and between your shoulder blades.

Researchers now believe that brown fat may hold the key to wellness, and by restoring your levels you may be able to significantly improve your health.

The reasons for losing brown fat as you age are complex, but we know that its loss can seriously impact your metabolic function, your cells’ ability to use insulin effectively, and mitochondrial biogenesis, or the production of new mitochondria.

Here’s where the science becomes very exciting... Mice studies show that the beta-lapachone found in Pau d’Arco bark can convert white fat into brown fat.

One eye-opening study even showed that beta-lapachone along with a high-fat diet stimulated the expression of brown-adipocyte genes, decreased weight gain and higher energy expenditure, compared to a control group of mice.

By using their plentiful mitochondria, brown fat cells may help regulate body weight and protect your vital organs, especially your heart and nervous system.

I’m sure you can conclude as I have, that having adequate brown fat in your body is a plus for weight management, mitochondrial health, and your heart and nervous system!

“We’ve Discovered THE Most Potent Longevity-Extending Pharmacological Intervention Ever Described in the Scientific Literature!”

As you can imagine, that quote really caught my attention while doing research for my “mitochondrial sauce.”

white willow bark research
Researchers were stunned to discover the longevity effects of white willow bark on yeast

This profound statement came out of recent research on the effects of plant compounds on the lifespan of the yeast, Saccharomyces cerevisiae.

Saccharomyces cells are often used in longevity studies because they act much like mammalian cells. They age and die in a similar manner, and their lifespan can be increased by calorie restriction.

In this study, researchers isolated six new groups of molecules that slow down the chronological aging of yeast.

At the top of their list, an extract of white willow bark (Salix alba) increased the average lifespan of yeast by 475 percent and the maximum chronological lifespan by 369 percent – making it the most potent longevity-extending pharmacological intervention ever described in scientific literature.

Think about it… that’s a nearly five-fold extension in lifespan for this yeast!

And what’s especially noteworthy about these results is the yeast cells were not food-restricted. They were cultivated in two percent glucose.

This clearly shows that willow bark mimics calorie restriction, potentially by activating the same biochemical pathways.

So what is it about white willow bark that enables it to achieve such dramatic results?

Could This Herb Boost Your Numbers of Mitochondria as Much as Three-Fold, With No Negative Drug Effects?

When you consume willow bark, your liver metabolizes its major constituent – salicin – to salicylic acid, the same substance created in your body within just minutes of taking a dose of aspirin.

Researchers have learned that aspirin – and salicylic acid – may promote the production of new mitochondria in your cells by turning on SIRT1, the master regulator protein we talked about earlier.

salicin in white willow bark
The salicin in white willow bark has mitochondrial-stimulating effects once it’s converted to salicylic acid in your liver

A recent study with liver cells found that both aspirin and salicylic acid, by itself, increased the total concentration of mitochondria by two to three times.

This discovery has researchers suspecting that the positive effects seen with aspirin might actually be from salicylic acid, and not aspirin per se!

Although highly debatable (in my opinion), some believe that low-dose aspirin therapy may offer potential benefits to certain individuals.

I think white willow bark may be a much better option.

Because willow bark converts to salicylic acid in your liver, you get all its potential benefits without any of aspirin’s negative effects, even with low doses!*

And here’s one more potential benefit of white willow bark… Salicin, like calorie restriction, may help control iron in your body.* Iron overload is a serious, yet largely overlooked organ-damaging problem that’s common in men, and women above childbearing years.

From Being Applauded for What They Don’t Contain to Spotlighting Them for Their Healthy Components: Mushrooms Go Center Stage

Remember the days when everyone loved mushrooms because they contained nothing? No calories, no fat, no sodium, no cholesterol. Truly the dieter’s dream!

Mushrooms: source of ergothioneine
Mushrooms are an outstanding source of ergothioneine

Now, we’re finally learning about their many valuable health-promoting qualities.

One of mushroom’s greatest benefits was discovered in 1909, but remained largely unrecognized until just recently.

Ergothioneine is a sulfur-containing amino acid that can only be produced by mushrooms, fungi, and a few soil bacteria.

Found in all of your tissues, ergothioneine accumulates in organs and cells that are typically exposed to high levels of oxidative stress, such as your red blood cells, liver, kidneys, and eye tissue. Your cells’ plasma membranes and mitochondria contain high concentrations of ergothioneine.

Here is what’s unique about ergothioneine:

  • Acts as a “master antioxidant” where it is transported to cells throughout your body to fight damage from oxidative stress and toxic free radicals
  • It’s the only known dietary substance with a specific gene and transport system that allows it to be actively transported across the cell membrane into the cell, enabling high concentrations in tissue
  • Has an extremely long half-life in your body – about 30 days of activity compared with 30 seconds to 30 minutes for many other antioxidants
  • It’s very stable when exposed to heat and acidity, an unusual trait for antioxidants
  • Can help protect against neurotoxins linked to cognitive decline

I’m especially interested in ergothioneine for its crucial role in protecting mitochondrial DNA from the reactive oxygen species and UV radiation.

Because the ergothioneine in your mitochondria is so stable and plentiful, it serves as a final line of defense for cells against oxidative damage. It helps your mitochondria cope with the overwhelming stress they endure during normal metabolism and energy production within the cells.

The King Trumpet Mushroom – Abundant in Ergothioneine, Beta-Glucans, and Polysaccharides

king trumpets mushrooms
King Trumpets are known for their beta-glucans and polysaccharides

The King Trumpet, or the King Oyster mushroom as it is also called, is known by the genus Pleurotus eryngii.

Along with its noteworthy health-supporting qualities, it’s also renowned for its ability to degrade environmental toxins and pollution.

King Trumpets are modulators. In other words, they regulate and influence your normal blood lipid levels and immune function, and healthy, normal cells.*

In fact, when compared to highly valued shiitake, button, and enoki mushrooms, oyster mushrooms surpass them for these potential benefits:

  • Have the ability to up-regulate important genes*
  • Contain biologically active beta-glucans known for their immune-supporting activity and antioxidant qualities*
  • Contain polysaccharides that provide energy for gut bacteria in your GI tract through fermentation*

Researchers have become particularly interested in King Trumpets’ polysaccharides as they believe they are one of the most significant active components in numerous life processes.*

In a study of mice fed the polysaccharides from Pleurotus eryngii, high doses created significant differences in the short-chain fatty acid concentration, pH value, and moisture contents of the mice’s colon contents, all positive changes.*

Levels of certain beneficial microorganisms were also increased, suggesting that King Trumpets could play a valuable role in supporting GI heath.*

And Last but Not Least… Organic Hawthorn Berry Fruit for the Support of Your Heart*

Organic Hawthorne Berry
Hawthorne has a long history of use

Every part of the hawthorn berry bush has been used for health, way back to ancient Greece and Asia, including its tiny berries and flowers, leaves, stems and even the bark.

One of the oldest-known plants used for health, hawthorn was first recorded as beneficial for heart health in the first century by Greek herbalist Dioscorides.*

Its use finally reached the U.S. by 1896, but by the 1930s, its popularity had evaporated.

Today hawthorn is making a comeback as its many benefits are being rediscovered. It’s now an ingredient in 213 commercial European herbal formulas, many for supporting cardiovascular health.*

Your heart is one of, if not your highest energy organ and requires well-functioning mitochondria. If your mitochondria are not working at their optimal best, your heart health can be at risk.

When your mitochondria are effectively able to burn fat for fuel, your heart receives the energy it needs to function properly.

In addition to its valuable support for your mitochondria and your heart, arteries, blood vessels, and blood flow, hawthorn berry also has documented benefits for:

  • Memory and cognitive health*
  • Promoting deep sleep*
  • Kidney health*
  • Relaxation and general well-being*
  • Menopausal symptom relief*
  • Blood sugar values that are already in the normal range*

Hawthorn berry contains a wealth of valuable active compounds: flavonoids, saponins, proanthocyanidins, phenolic acids, and other antioxidants. In fact, out of 28 different fruit pulps tested, hawthorn produced the highest measure of antioxidant activity.

In short, hawthorn berry offers potential benefits for a majority of the adult population. More people today than ever are taking an interest in supporting their heart and vascular health, cognitive health, and ability to relax and sleep soundly.*

Introducing MITOMIX® Ketogenic Blend

Now you have it. Now you know my secret mitochondrial sauce! 

Can you see why I’m so excited?  I have been taking the individual elements of this mixture for over two years but have finally put them all into one mixture for my and your convenience.

I knew not everyone would be willing to go out and hunt down all these separate ingredients. So, I asked my team to help me put together my special MITOMIX® Ketogenic Blend – my mitochondrial sauce, if you will – with these four botanicals: Pau d’Arco, White Willow Bark, Organic King Trumpet Mushroom, and Organic Hawthorn Berry Fruit.

After doing our research and selecting only the finest quality plant ingredients available, MITOMIX® Ketogenic Blend is now ready for you.

Give Your Mitochondria the Red Carpet Treatment They Deserve… Order MITOMIX® Ketogenic Blend Today!

You want to live a full and active life. And now you know that your ability to live a long, youthful life largely depends on the number of healthy and functioning mitochondria you have in your cells, especially cells in those high-energy demanding organs like your heart, brain, nervous system, kidneys, and muscles.

Your mitochondria are under constant assault – and some of the worst damage occurs when they’re doing their job – fueling your body! They need protection, and they need it every day.

That’s what I’ve designed MITOMIX® Ketogenic Blend to do: support the healthy regeneration and maintenance of your mitochondria – in all your cells.*

Available in powder form, simply add a scoop of MITOMIX® Ketogenic Blend to hot water for a soothing tea, or add to your favorite drink or smoothie recipe any time of day. Its smooth flavor tastes much like a mild herbal tea.

Don’t delay another day. Life is too precious. Order MITOMIX® Ketogenic Blend today!

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  1. Because this newer research is so exciting, certain manufacturers are rushing NAD+ synthetic precursors NMN and NR (nicotinamide riboside) to market.

    Some individuals are even experimenting with direct IV infusion of NAD, which is something I do not recommend at this time. Not only is straight NAD+ costly, we don’t know everything about what it does in the body and how it interacts with other functions. Studies also show that taking NAD+ directly is ineffective and less effective than using a reliable NAD+ precursor.

    The end result is the same (the potential for enhanced well-being and longevity), but I prefer to take a more natural and holistic approach – one that relies on herbal and mushroom precursors rather than synthetic substances concocted in a lab. It costs a fraction of the price to get these amazing benefits and I believe it’s less risky.

  2. MITOMIX® Ketogenic Blend is made up of whole foods, not extracts, so it is not completely soluble in water. It can be mixed with 8oz of plain water and is best served hot like tea. Alternatively, add a scoop of MITOMIX® Ketogenic Blend along with my Organic Greens or add to your favorite shake recipe.

  3. MITOMIX® Ketogenic Blend contains ingredients that have mild blood thinning properties and may slow blood clotting. Therefore, those on certain heart medications or those with blood coagulation conditions should not use MITOMIX® Ketogenic Blend.

    White willow contains substances similar to those found in aspirin. Individuals on an aspirin regimen should consult with their physician before consuming ingredients containing white willow such as our MITOMIX® Ketogenic Blend.

  • If you have blood coagulation condition or are taking anticoagulants such as Warfarin (Coumadin®), do not use MITOMIX® Ketogenic Blend.

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